作者
Ewelina Pośpiech, Yan Chen, Magdalena Kukla-Bartoszek, Krystal Breslin, Anastasia Aliferi, Jeppe D Andersen, David Ballard, Lakshmi Chaitanya, Ana Freire-Aradas, Kristiaan J van der Gaag, Lorena Girón-Santamaría, Theresa E Gross, Mario Gysi, Gabriela Huber, Ana Mosquera-Miguel, Charanya Muralidharan, Małgorzata Skowron, Ángel Carracedo, Cordula Haas, Niels Morling, Walther Parson, Christopher Phillips, Peter M Schneider, Titia Sijen, Denise Syndercombe-Court, Marielle Vennemann, Sijie Wu, Shuhua Xu, Li Jin, Sijia Wang, Ghu Zhu, Nick G Martin, Sarah E Medland, Wojciech Branicki, Susan Walsh, Fan Liu, Manfred Kayser, EUROFORGEN-NoE Consortium
发表日期
2018/11/1
期刊
Forensic Science International: Genetics
卷号
37
页码范围
241-251
出版商
Elsevier
简介
Human head hair shape, commonly classified as straight, wavy, curly or frizzy, is an attractive target for Forensic DNA Phenotyping and other applications of human appearance prediction from DNA such as in paleogenetics. The genetic knowledge underlying head hair shape variation was recently improved by the outcome of a series of genome-wide association and replication studies in a total of 26,964 subjects, highlighting 12 loci of which 8 were novel and introducing a prediction model for Europeans based on 14 SNPs. In the present study, we evaluated the capacity of DNA-based head hair shape prediction by investigating an extended set of candidate SNP predictors and by using an independent set of samples for model validation. Prediction model building was carried out in 9674 subjects (6068 from Europe, 2899 from Asia and 707 of admixed European and Asian ancestries), used previously, by …
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E Pośpiech, Y Chen, M Kukla-Bartoszek, K Breslin… - Forensic Science International: Genetics, 2018