作者
Timothy Wilens, William Pelham, Mark Stein, C Keith Conners, Howard Abikoff, Marc Atkins, Gerald August, Laurence Greenhill, Keith McBurnett, Donna Palumbo, James Swanson, Mark Wolraich
发表日期
2003/4/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
42
期号
4
页码范围
424-433
出版商
Elsevier
简介
OBJECTIVE
Few treatment studies of attention-deficit/hyperactivity disorder (ADHD) extend beyond a few months. This article reports an interim analysis of a 24-month study evaluating the 12-month tolerability and effectiveness of a once-daily OROS® formulation of methylphenidate (OROS MPH) in children with ADHD.
METHOD
Children, aged 6–13 years, with ADHD who participated in previous controlled studies and were MPH responders, received once-daily OROS MPH in this multicenter, open-label, nonrandomized study. Effectiveness was evaluated monthly by parents/caregivers and schoolteachers using validated rating scales (e.g., IOWA Conners). Safety and adverse events assessments involved objective (e.g., vital signs, growth) and subjective (sleep quality, tics) reporting.
RESULTS
Seventy-one percent of subjects (289/407) completed 12 months’ treatment. Effectiveness was maintained throughout …
引用总数
学术搜索中的文章
T Wilens, W Pelham, M Stein, CK Conners, H Abikoff… - Journal of the American Academy of Child & …, 2003