作者
Erin M Bange, Nicholas A Han, Paul Wileyto, Justin Y Kim, Sigrid Gouma, James Robinson, Allison R Greenplate, Madeline A Hwee, Florence Porterfield, Olutosin Owoyemi, Karan Naik, Cathy Zheng, Michael Galantino, Ariel R Weisman, Caroline AG Ittner, Emily M Kugler, Amy E Baxter, Olutwatosin Oniyide, Roseline S Agyekum, Thomas G Dunn, Tiffanie K Jones, Heather M Giannini, Madison E Weirick, Christopher M McAllister, N Esther Babady, Anita Kumar, Adam J Widman, Susan DeWolf, Sawsan R Boutemine, Charlotte Roberts, Krista R Budzik, Susan Tollett, Carla Wright, Tara Perloff, Lova Sun, Divij Mathew, Josephine R Giles, Derek A Oldridge, Jennifer E Wu, Cécile Alanio, Sharon Adamski, Alfred L Garfall, Laura A Vella, Samuel J Kerr, Justine V Cohen, Randall A Oyer, Ryan Massa, Ivan P Maillard, Kara N Maxwell, John P Reilly, Peter G Maslak, Robert H Vonderheide, Jedd D Wolchok, Scott E Hensley, E John Wherry, Nuala J Meyer, Angela M DeMichele, Santosha A Vardhana, Ronac Mamtani, Alexander C Huang
发表日期
2021/7
期刊
Nature medicine
卷号
27
期号
7
页码范围
1280-1289
出版商
Nature Publishing Group US
简介
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hospitalized for COVID-19, patients with hematologic cancer had higher mortality relative to patients with solid cancer. In two additional cohorts, flow cytometric and serologic analyses demonstrated that patients with solid cancer and patients without cancer had a similar immune phenotype during acute COVID-19, whereas patients with hematologic cancer had impairment of B cells and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody responses. Despite the impaired humoral immunity and high mortality in patients with hematologic cancer who also have COVID-19, those with a greater number of CD8 T cells had improved survival, including those treated with anti-CD20 …
学术搜索中的文章
EM Bange, NA Han, P Wileyto, JY Kim, S Gouma… - Nature medicine, 2021