作者
Divij Mathew, Josephine R Giles, Amy E Baxter, Derek A Oldridge, Allison R Greenplate, Jennifer E Wu, Cécile Alanio, Leticia Kuri-Cervantes, M Betina Pampena, Kurt D’Andrea, Sasikanth Manne, Zeyu Chen, Yinghui Jane Huang, John P Reilly, Ariel R Weisman, Caroline AG Ittner, Oliva Kuthuru, Jeanette Dougherty, Kito Nzingha, Nicholas Han, Justin Kim, Ajinkya Pattekar, Eileen C Goodwin, Elizabeth M Anderson, Madison E Weirick, Sigrid Gouma, Claudia P Arevalo, Marcus J Bolton, Fang Chen, Simon F Lacey, Holly Ramage, Sara Cherry, Scott E Hensley, Sokratis A Apostolidis, Alexander C Huang, Laura A Vella, UPenn COVID Processing Unit†, Michael R Betts, Nuala J Meyer, E John Wherry
发表日期
2020/9/4
期刊
Science
卷号
369
期号
6508
页码范围
eabc8511
出版商
American Association for the Advancement of Science
简介
INTRODUCTION
Many patients with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe respiratory disease requiring hospitalization and mechanical ventilation. Although most patients recover, disease is complex and case fatality can be as high as 10%. How human immune responses control or exacerbate COVID-19 is currently poorly understood, and defining the nature of immune responses during acute COVID-19 could help identify therapeutics and effective vaccines.
RATIONALE
Immune dysregulation during SARS-CoV-2 infection has been implicated in pathogenesis, but currently available data remain limited. We used high-dimensional cytometry to analyze COVID-19 patients and compare them with recovered and healthy individuals and performed integrated analysis of ~200 immune features. These data …
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