作者
Pierre Delanaye, Kitty J Jager, Arend Bökenkamp, Anders Christensson, Laurence Dubourg, Bjørn Odvar Eriksen, François Gaillard, Giovanni Gambaro, Markus van Der Giet, Richard J Glassock, Olafur S Indridason, Marco Van Londen, Christophe Mariat, Toralf Melsom, Olivier Moranne, Gunnar Nordin, Runolfur Palsson, Hans Pottel, Andrew D Rule, Elke Schaeffner, Maarten W Taal, Christine White, Anders Grubb, Jan AJG Van Den Brand
发表日期
2019/10/1
来源
Journal of the American Society of Nephrology
卷号
30
期号
10
页码范围
1785-1805
出版商
LWW
简介
Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m 2. This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that GFR declines with healthy aging without any overt signs of compensation (such as elevated single-nephron GFR) or kidney damage. Older living kidney donors, who are carefully selected based on good health, have a lower predonation GFR compared with younger donors. Furthermore, the results from the large meta-analyses conducted by the CKD Prognosis Consortium and from numerous other studies indicate that the GFR threshold above which the risk of mortality is increased is not consistent across all ages. Among …
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P Delanaye, KJ Jager, A Bökenkamp, A Christensson… - Journal of the American Society of Nephrology, 2019