作者
Guoying Zhou, Dave Sprengers, Patrick PC Boor, Michail Doukas, Hannah Schutz, Shanta Mancham, Alexander Pedroza-Gonzalez, Wojciech G Polak, Jeroen De Jonge, Marcia Gaspersz, Haidong Dong, Kris Thielemans, Qiuwei Pan, Jan NM IJzermans, Marco J Bruno, Jaap Kwekkeboom
发表日期
2017/10/1
期刊
Gastroenterology
卷号
153
期号
4
页码范围
1107-1119. e10
出版商
WB Saunders
简介
Background & Aims
Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), down-regulates the T-cell–mediated immune response (called immune checkpoints). Antibodies that block these receptors increase antitumor immunity in patients with melanoma, non–small-cell lung cancer, and renal cell cancer. Tumor-infiltrating CD4+ and CD8+ T cells in patients with hepatocellular carcinoma (HCC) have been found to be functionally compromised. We analyzed HCC samples from patients to determine if these inhibitory pathways prevent T-cell responses in HCCs and to find ways to restore their antitumor functions.
Methods
We collected HCC samples from 59 patients who underwent surgical resection from November 2013 through May 2017, along with tumor-free liver tissues (control tissues) and peripheral blood …
学术搜索中的文章
G Zhou, D Sprengers, PPC Boor, M Doukas, H Schutz… - Gastroenterology, 2017