作者
Micheline Misrahi, Jean-Paul Teglas, Nicole N'Go, Marianne Burgard, Marie-Jeanne Mayaux, Christine Rouzioux, Jean-François Delfraissy, Stéphane Blanche, French Pediatric HIV Infection Study Group, French Pediatric HIV Infection Study Group
发表日期
1998/1/28
期刊
Jama
卷号
279
期号
4
页码范围
277-280
出版商
American Medical Association
简介
Context
Studies suggest that adults with the CCR5Δ32 deletion are less likely to become infected with the human immunodeficiency virus (HIV) and to develop HIV-related disease progression, but the effect of the mutation in children is not known.
Objective
To study the effect of the CCR5 chemokine receptor mutant allele on mother-to-child transmission of HIV type 1 (HIV-1) and subsequent disease progression in infected children.
Design
Multicenter, prospective study of infants born to mothers seropositive for HIV-1.
Setting
A total of 52 medical centers participating in the French Pediatric HIV Cohort studies.
Participants
The CCR5Δ32 deletion was studied in 512 non-African children, born between 1983 and 1996 to HIV-1–infected mothers. Among them, 276 children were infected and 236 were not.
Main Outcome Measures
HIV-1 infection status and, in infected children followed up since birth, incidence of category B …
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学术搜索中的文章
M Misrahi, JP Teglas, N N'Go, M Burgard, MJ Mayaux… - Jama, 1998