作者
Sridevi Devaraj, Surekha Mathur, Arpita Basu, Hnin H Aung, Vihas T Vasu, Stuart Meyers, Ishwarlal Jialal
发表日期
2008/4/1
期刊
Journal of the American College of Nutrition
卷号
27
期号
2
页码范围
267-273
出版商
Routledge
简介
Objective: While tomato product supplementation, containing antioxidant carotenoids, including lycopene, decreases oxidative stress, the role of purified lycopene as an antioxidant remains unclear. Thus, we tested the effects of different doses of purified lycopene supplementation on biomarkers of oxidative stress in healthy volunteers.
Methods: This was a double-blind, randomized, placebo-controlled trial, examining the effects of 8-week supplementation of purified lycopene, on plasma lycopene levels, biomarkers of lipid peroxidation {LDL oxidizability, malondialdehyde & hydroxynonenals (MDA & HNE), urinary F2-isoprostanes}, and markers of DNA damage in urine and lymphocytes. Healthy adults (n = 77, age ≥ 40 years), consumed a lycopene-restricted diet for 2 weeks, and were then randomized to receive 0, 6.5, 15, or 30 mg lycopene/ day for 8 weeks, while on the lycopene-restricted diet. Blood and urine …
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S Devaraj, S Mathur, A Basu, HH Aung, VT Vasu… - Journal of the American College of Nutrition, 2008