作者
AJM Ferreri, M Reni, F Pasini, A Calderoni, U Tirelli, A Pivnik, GM Aondio, F Ferrarese, H Gomez, Maurilio Ponzoni, B Borisch, F Berger, C Chassagne, P Iuzzolino, A Carbone, J Weis, E Pedrinis, T Motta, A Jouvet, T Barbui, F Cavalli, J-Y Blay
发表日期
2002/5/28
期刊
Neurology
卷号
58
期号
10
页码范围
1513-1520
出版商
Lippincott Williams & Wilkins
简介
Objective: To characterize the therapeutic variables correlated to outcome in 370 patients with primary CNS lymphoma.
Methods: Planned treatment was radiotherapy (RT) in 98 patients, chemotherapy (CHT) in 32, RT followed by CHT in 36, and CHT followed by RT in 197 patients. High-dose methotrexate (HD-MTX; 1 to 8 g/m2) was used in 169 patients and intrathecal CHT in 109.
Results: One hundred sixteen patients are alive (median follow-up 24 months), with a 2-year overall survival of 37%. Patients treated with CHT followed by RT had improved survival with respect to patients treated with RT alone. Patients receiving HD-MTX–based primary CHT survived longer than those treated with other drugs. HD-MTX associated with other cytostatics, in particular HD-cytarabine, produced better results than HD-MTX alone. No correlation between MTX dose and survival was found. In patients receiving HD …
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AJM Ferreri, M Reni, F Pasini, A Calderoni, U Tirelli… - Neurology, 2002