查看文章

Objective:

To determine whether pericontusional tissue exhibits neurochemical responsiveness to changes in cerebral perfusion pressure as measured by microdialysis lactate/pyruvate ratio.

Design:

Prospective monitoring with retrospective data analysis.

Setting:

Single-center academic neurologic intensive care unit.

Patients:

Twenty-one patients with severe traumatic brain injury (Glasgow Coma Scale score 3–8).

Interventions:

None.

Measurements and Main Results:

Cerebral microdialysis was performed for the initial 7 days after traumatic brain injury. Thirteen patients had microdialysis probes in normal tissue and eight had two probes, one of which was located in pericontusional tissue. Retrospective analysis was performed to determine if microdialysis levels in pericontusional tissue demonstrates higher levels of lactate/pyruvate ratio than normal tissue and if lactate/pyruvate ratio increased with reductions in …