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Objective:

To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio.

Design:

Prospective monitoring with retrospective data analysis.

Setting:

Single center academic neurologic intensive care unit.

Patients:

Twenty moderate to severe traumatic brain injury patients (Glasgow Coma Score 3–13).

Measurements and Main Results:

Continuous electroencephalography and cerebral microdialysis were performed for 7 days after injury. Ten patients had seizures and were compared with a matched cohort of traumatic brain injury patients without seizures. The seizures were repetitive and constituted status epilepticus in seven of ten patients. Using a within-subject design, post-traumatic seizures resulted in episodic increases in intracranial pressure (22.4±7 vs. 12.8±4.3 mm Hg; p<. 001) and an episodic increase in lactate …