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Methods: Treatment naïve patients with chronic HBV infection were enrolled in the study. Demographic factors, history and clinical findings were recorded. Hemogram, biochemical parameters including liver function tests were assayed in all cases. HBeAg and antiHBe antibody assays were done. Quantification of HBsAg and HBV-DNA was done in serum. HBsAg quantification was done using chemiluminescence immunoassay (Roche diagnositics) and expressed in IU/ml. HBV quantification was done using real time PCR assay (SYBR-Green or COBAS TaqMan) and expressed in IU/ml. Pearson correlation coefficient was used to assess the correlation between serum quantitative HBsAg levels and quantitative HBV-DNA levels. SPSS v14 was used for statistical analysis and P value of< 0.05 was considered significant.

Results: Two hundred and twenty-eight patients were enrolled in the study of which 149 (65.4 …