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Metastases are the main cause of death in breast cancer patients. Among breast metastatic sites, bone is the most prevalent site that can also seed secondary metastases. Moreover, once tumor cells reach the bone, the disease is considered incurable and treatments are only palliative. For this reason, new therapies that limit metastatic growth are desperately needed. We previously showed that pharmacological inhibition of p38MAPKα (p38i) limited visceral and bone metastases in several clinically relevant models of breast cancer metastasis. Indeed, we found that this approach had no impact on tumor cells but instead limited the supporting nature of the stromal compartment. These findings led us to ask how p38i impacted the stromal compartment. Using a novel strategy to segregate tumor-infiltrating from non-tumor-infiltrating stromal cells in the bone metastatic site, we carried out single cell RNA sequencing …