作者
Juan Manuel Figueroa, Mónica Edith Lombardo, Ariel Dogliotti, Luis Pedro Flynn, Robert Giugliano, Guido Simonelli, Ricardo Valentini, Agñel Ramos, Pablo Romano, Marcelo Marcote, Alicia Michelini, Alejandro Salvado, Emilio Sykora, Cecilia Kniz, Marcelo Kobelinsky, David Manuel Salzberg, Diana Jerusalinsky, Osvaldo Uchitel
发表日期
2021/10/1
期刊
International Journal of General Medicine
页码范围
6277-6286
出版商
Taylor & Francis
简介
Background
Iota-Carrageenan (I-C) is a sulfate polysaccharide synthesized by red algae, with demonstrated antiviral activity and clinical efficacy as nasal spray in the treatment of common cold. In vitro, I-C inhibits SARS-CoV-2 infection in cell culture.
Research Question
Can a nasal spray with Iota-Carrageenan be useful in the prophylaxis of COVID-19 in health care workers managing patients with COVID-19 disease?
Study Design and Methods
This is a pilot pragmatic multicenter, randomized, double-blind, placebo-controlled study assessing the use of a nasal spray containing I-C in the prophylaxis of COVID-19 in hospital personnel dedicated to care of COVID-19 patients. Clinically healthy physicians, nurses, kinesiologists and other health care providers managing patients hospitalized for COVID-19 were assigned in a 1:1 ratio to receive four daily doses of I-C spray or placebo for 21 days. The primary end point …
学术搜索中的文章
JM Figueroa, ME Lombardo, A Dogliotti, LP Flynn… - International Journal of General Medicine, 2021