作者
Livio Pagano, Morena Caira, Anna Candoni, Franco Aversa, Carlo Castagnola, Cecilia Caramatti, Chiara Cattaneo, Mario Delia, Maria Rosaria De Paolis, Roberta Di Blasi, Luigi Di Caprio, Rosa Fanci, Mariagrazia Garzia, Bruno Martino, Lorella Melillo, Maria Enza Mitra, Gianpaolo Nadali, Annamaria Nosari, Marco Picardi, Leonardo Potenza, Prassede Salutari, Enrico Maria Trecarichi, Mario Tumbarello, Luisa Verga, Nicola Vianelli, Alessandro Busca, SEIFEM Group
发表日期
2012/12/1
期刊
Clinical infectious diseases
卷号
55
期号
11
页码范围
1515-1521
出版商
Oxford University Press
简介
Background. To analyze the efficacy of antifungal prophylaxis (AFP) with posaconazole and itraconazole in a real-life setting of patients with acute myeloid leukemia (AML) during the first induction of remission.
Methods. From January 2010 to June 2011, all patients with newly diagnosed AML were consecutively registered and prospectively monitored at 30 Italian hematological centers. Our analysis focused on adult patients who received intensive chemotherapy and a mold-active AFP for at least 5 days. To determine the efficacy of prophylaxis, invasive fungal disease (IFD) incidence, IFD-attributable mortality, and overall survival were evaluated.
Results. In total, 515 patients were included in the present analysis. Posaconazole was the most frequently prescribed drug (260 patients [50%]) followed by fluconazole (148 [29%]) and …
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L Pagano, M Caira, A Candoni, F Aversa… - Clinical infectious diseases, 2012