作者
Constantin Lapa, Malte Kircher, Matteo Da Via, Martin Schreder, Leo Rasche, K Martin Kortüm, Hermann Einsele, Andreas K Buck, Heribert Hänscheid, Samuel Samnick
发表日期
2019/8/1
期刊
Clinical nuclear medicine
卷号
44
期号
8
页码范围
620-624
出版商
LWW
简介
Purpose
PET/CT with both 11 C-choline and 11 C-methionine has recently been reported to offer advantages over 18 F-FDG for imaging in multiple myeloma (MM). The aim of this study was to directly compare the diagnostic performance of both non-FDG radiotracers in MM patients.
Methods
Nineteen patients with a history of MM (n= 18) or solitary bone plasmacytoma (n= 1) underwent both 11 C-choline and 11 C-methionine PET/CT for diagnostic imaging. In this retrospective analysis, scans were compared on a patient and on a lesion basis. In 12 patients, respective tracer uptake in the iliac crest was correlated with the extent of malignant bone marrow plasma cell infiltration.
Results
11 C-methionine detected more intramedullary MM lesions in 8 (42.1%) of 19 patients. In the remainder (11/19 [57.9%]), both 11 C-choline and 11 C-methionine provided equal results. 11 C-methionine demonstrated higher lesion-to …
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C Lapa, M Kircher, M Da Via, M Schreder, L Rasche… - Clinical nuclear medicine, 2019