作者
HM Pallavi, Fares Hezam Al-Ostoot, Hamse Kameshwar Vivek, Shaukath Ara Khanum
发表日期
2022/1/5
期刊
Journal of Molecular Structure
卷号
1247
页码范围
131404
出版商
Elsevier
简介
Inflammation is the complex biological response of vascular tissues, which is partly determined by prostaglandins (PLA2). The cyclooxygenase (COX) enzyme exists in two isoforms: COX-1 and COX-2 and by the action of this, the PGs are produced. Besides, nonsteroidal anti-inflammatory drugs (NSAIDs) are therapeutic agents useful in the treatment of inflammation. Encouraged by this, the new derivatives of N'(2-phenoxyacetyl)nicotinohydrazide 9(a-e) and N'(2-phenoxyacetyl)isonicotinohydrazide 10(a-e) were designed, synthesized, characterized, and identified as remarkable anti-inflammatory and analgesic agents. These compounds were prepared in a series of steps starting with different phenol derivatives. Among the series, compound (10e) showed the highest IC50 value for COX-1 inhibition, whereas compounds (9e) and (10e) exhibited the highest COX-2SI. Further, molecular Docking Studies have been …
学术搜索中的文章
HM Pallavi, FH Al-Ostoot, HK Vivek, SA Khanum - Journal of Molecular Structure, 2022