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Kupffer cell and macrophage (MØ) activation contributes to steatosis, inflammation, and fibrosis in alcoholic liver disease (ALD). We found increased frequency of MØ, T cells, and expression of C‐C chemokine receptor type 2 (Ccr2) and C‐C chemokine receptor type 5 (Ccr5) in the livers of patients with ALD, and increased circulating chemokines, C‐C chemokine ligand types 2 (CCL2), and C‐C chemokine ligand types 5 (CCL5) in patients with alcoholic hepatitis. We hypothesized that inhibition of CCL2 signaling with the dual CCR2/5 inhibitor, cenicriviroc (CVC), would attenuate ALD. In a mouse model of ALD, liver injury (alanine aminotransferase [ALT]) and steatosis were prevented by CVC whether administered as “prevention” throughout the alcohol feeding or as “treatment” started after the development of ALD. Alcohol‐induced increases in early liver fibrosis markers (sirius red, hydroxyproline, and collagen‐1 …