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The emergence of multidrug resistance (MDR), extensively drug‐resistant, and total drug‐resistant Mycobacterium tuberculosis (Mtb) strains have hampered the treatment of tuberculosis (TB). Capreomycin and Bedaquiline are currently used for MDR‐TB treatment. To understand the impact of these antibiotics on Mtb genes, we have curated the gene expression data where the Mtb cultures were exposed to the Bedaquiline and Capreomycin. Based on the P value cut off (<0.05) and logFC (<−0.5 and >+0.5) values, we have selected the top differentially expressed genes during the antibiotic exposures. We have observed that the top differentially expressed Mtb genes were related to universal stress genes, two‐component regulatory systems, and drug efflux pumps. We have curated the Mtb gene datasets and carried out the functional over‐representation analysis using the individual gene expression values. We …