作者
Eric X Chen, Jonathan M Loree, Emma Titmuss, Derek J Jonker, Hagen F Kennecke, Scott Berry, Felix Couture, Chaudharry E Ahmad, John R Goffin, Petr Kavan, Mohammed Harb, Bruce Colwell, Setareh Samimi, Benoit Samson, Tahir Abbas, Nathalie Aucoin, Francine Aubin, Sheryl Koski, Alice C Wei, Dongsheng Tu, Chris J O’Callaghan
发表日期
2023/12/1
期刊
JAMA Network Open
卷号
6
期号
12
页码范围
e2346094-e2346094
出版商
American Medical Association
简介
Importance
Immune checkpoint inhibitors (ICIs) have limited activity in microsatellite-stable (MSS) or mismatch repair–proficient (pMMR) colorectal cancer. Recent findings suggest the efficacy of ICIs may be modulated by the presence of liver metastases (LM).
Objective
To investigate the association between the presence of LM and ICI activity in advanced MSS colorectal cancer.
Design, Setting, and Participants
In this secondary analysis of the Canadian Cancer Trials Group CO26 (CCTG CO.26) randomized clinical trial, patients with treatment-refractory colorectal cancer were randomized in a 2:1 fashion to durvalumab plus tremelimumab or best supportive care alone between August 10, 2016, and June 15, 2017. The primary end point was overall survival (OS) with 80% power and 2-sided α = .10. The median follow-up was 15.2 (0.2-22.0) months. In this post hoc analysis performed from February 11 to 14, 2022 …
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EX Chen, JM Loree, E Titmuss, DJ Jonker… - JAMA Network Open, 2023