作者
Stevan R Hubbard, Lei Wei, Wayne A Hendrickson
发表日期
1994/12/29
期刊
Nature
卷号
372
期号
6508
页码范围
746-754
出版商
Nature Publishing Group UK
简介
The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 Å resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.
引用总数
学术搜索中的文章
SR Hubbard, L Wei, WA Hendrickson - Nature, 1994