作者
Ramon Diaz-Arrastia, Kevin KW Wang, Linda Papa, Marco D Sorani, John K Yue, Ava M Puccio, Paul J McMahon, Tomoo Inoue, Esther L Yuh, Hester F Lingsma, Andrew IR Maas, Alex B Valadka, David O Okonkwo, Geoffrey T Manley and the TRACK-TBI Investigators, including Scott S Casey, Maxwell Cheong, Shelly R Cooper, Kristen Dams-O'Connor, Wayne A Gordon, Allison J Hricik, David K Menon, Pratik Mukherjee, David M Schnyer, Tuhin K Sinha, Mary J Vassar
发表日期
2014/1/1
期刊
Journal of neurotrauma
卷号
31
期号
1
页码范围
19-25
出版商
Mary Ann Liebert, Inc.
简介
Biomarkers are important for accurate diagnosis of complex disorders such as traumatic brain injury (TBI). For a complex and multifaceted condition such as TBI, it is likely that a single biomarker will not reflect the full spectrum of the response of brain tissue to injury. Ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) are among of the most widely studied biomarkers for TBI. Because UCH-L1 and GFAP measure distinct molecular events, we hypothesized that analysis of both biomarkers would be superior to analysis of each alone for the diagnosis and prognosis of TBI. Serum levels of UCH-L1 and GFAP were measured in a cohort of 206 patients with TBI enrolled in a multicenter observational study (Transforming Research and Clinical Knowledge in Traumatic Brain Injury [TRACK-TBI]). Levels of the two biomarkers were weakly correlated to each other (r=0.364). Each biomarker in …
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R Diaz-Arrastia, KKW Wang, L Papa, MD Sorani… - Journal of neurotrauma, 2014
