作者
Frederick K Korley, Ramon Diaz-Arrastia, Alan HB Wu, John K Yue, Geoffrey T Manley, Haris I Sair, Jennifer Van Eyk, Allen D Everett, TRACK-TBI investigators including, David O Okonkwo, Alex B Valadka, Wayne A Gordon, Andrew IR Maas, Pratik Mukherjee, Esther L Yuh, Hester F Lingsma, Ava M Puccio, David M Schnyer
发表日期
2016/1/15
期刊
Journal of neurotrauma
卷号
33
期号
2
页码范围
215-225
出版商
Mary Ann Liebert, Inc.
简介
Brain-derived neurotrophic factor (BDNF) is important for neuronal survival and regeneration. We investigated the diagnostic and prognostic values of serum BDNF in traumatic brain injury (TBI). We examined serum BDNF in two independent cohorts of TBI cases presenting to the emergency departments (EDs) of the Johns Hopkins Hospital (JHH; n = 76) and San Francisco General Hospital (SFGH, n = 80), and a control group of JHH ED patients without TBI (n = 150). Findings were subsequently validated in the prospective, multi-center Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) Pilot study (n = 159). We investigated the association between BDNF, glial fibrillary acidic protein (GFAP), and ubiquitin C-terminal hydrolase-L1 (UCH-L1) and recovery from TBI at 6 months in the TRACK-TBI Pilot cohort. Incomplete recovery was defined as having either post-concussive syndrome or a …
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FK Korley, R Diaz-Arrastia, AHB Wu, JK Yue… - Journal of neurotrauma, 2016
