作者
Nicola Pritchard, Katie Edwards, Cirous Dehghani, Hassan Fadavi, Maria Jeziorska, Andrew Marshall, Ioannis N Petropoulos, Georgios Ponirakis, Anthony W Russell, Geoff P Sampson, Ayda M Shahidi, Sangeetha Srinivasan, Mitra Tavakoli, Dimitrios Vagenas, Rayaz A Malik, Nathan Efron
发表日期
2014/5/1
期刊
Diabetes research and clinical practice
卷号
104
期号
2
页码范围
248-256
出版商
Elsevier
简介
Aims
Corneal nerve morphology and corneal sensation threshold have recently been explored as potential surrogate markers for the evaluation of diabetic neuropathy. We present the baseline findings of the ‘Longitudinal Assessment of Neuropathy in type 1 Diabetes using novel ophthalmic Markers’(LANDMark) study.
Methods
The LANDMark study is a 4-year, two-site, natural history study of three participant groups: type 1 diabetes with neuropathy (T1W), type 1 diabetes without neuropathy (T1WO) and control participants without diabetes or neuropathy. All participants undergo a detailed annual assessment of neuropathy including corneal nerve parameters measured using corneal confocal microscopy and corneal sensitivity measured using non-contact corneal aesthesiometry.
Results
76 T1W, 166 T1WO and 154 control participants were enrolled into the study. Corneal sensation threshold was significantly …
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N Pritchard, K Edwards, C Dehghani, H Fadavi… - Diabetes research and clinical practice, 2014