作者
Silas A Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H Bhatte, Victoria C Childers, Sophie A Rubin, Briana R De Miranda, Emma I O'Leary, Elizabeth G Neureiter, Keri J Fogle, Michael J Palladino, Ryan W Logan, Jill R Glausier, Kenneth N Fish, David A Lewis, J Timothy Greenamyre, Brian D McCabe, Claire EJ Cheetham, Thomas S Hnasko, Zachary Freyberg
发表日期
2021/5
期刊
Aging cell
卷号
20
期号
5
页码范围
e13365
简介
Age is the greatest risk factor for Parkinson's disease (PD) which causes progressive loss of dopamine (DA) neurons, with males at greater risk than females. Intriguingly, some DA neurons are more resilient to degeneration than others. Increasing evidence suggests that vesicular glutamate transporter (VGLUT) expression in DA neurons plays a role in this selective vulnerability. We investigated the role of DA neuron VGLUT in sex‐ and age‐related differences in DA neuron vulnerability using the genetically tractable Drosophila model. We found sex differences in age‐related DA neurodegeneration and its associated locomotor behavior, where males exhibit significantly greater decreases in both DA neuron number and locomotion during aging compared with females. We discovered that dynamic changes in DA neuron VGLUT expression mediate these age‐ and sex‐related differences, as a potential …
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SA Buck, T Steinkellner, D Aslanoglou, M Villeneuve… - Aging cell, 2021