作者
E Dorsey, Maryam Zafar, Samantha E Lettenberger, Meghan E Pawlik, Dan Kinel, Myrthe Frissen, Ruth B Schneider, Karl Kieburtz, Caroline M Tanner, Briana R De Miranda, Samuel M Goldman, Bastiaan R Bloem
发表日期
2023/1/1
来源
Journal of Parkinson's disease
卷号
13
期号
2
页码范围
203-218
出版商
IOS Press
简介
The etiologies of Parkinson’s disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common environmental contaminant little recognized for its likely role in PD: trichloroethylene (TCE). TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes. The colorless chemical was first linked to parkinsonism in 1969. Since then, four case studies involving eight individuals have linked occupational exposure to TCE to PD. In addition, a small epidemiological study found that occupational or hobby exposure to the solvent was associated with a 500% increased risk of developing PD. In multiple animal studies, the chemical reproduces …
引用总数
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E Dorsey, M Zafar, SE Lettenberger, ME Pawlik… - Journal of Parkinson's disease, 2023