作者
Wanvisa Udomsinprasert, Tewin Tencomnao, Sittisak Honsawek, Wilai Anomasiri, Paisarn Vejchapipat, Voranush Chongsrisawat, Yong Poovorawan
发表日期
2012/11
期刊
World journal of pediatrics
卷号
8
页码范围
328-334
出版商
SP Children’s Hospital, Zhejiang University School of Medicine
简介
Background
Biliary atresia (BA) is an intractable neonatal inflammatory and obliterative cholangiopathy, leading to progressive fibrosis and cirrhosis. Adiponectin, an anti-inflammatory adipokine, is known to play a possible role in liver diseases. The objective of our study was to determine the relationship between adiponectin gene polymorphisms and BA susceptibility.
Methods
A total of 106 BA patients and 107 healthy controls were included in this study. Two single nucleotide polymorphisms (SNPs) of the adiponectin gene, +45T/G (rs2241766) and +276G/T (rs1501299), were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis.
Results
Genotype distributions of +45 T/G and +276 G/T SNPs were seen in the Hardy-Weinberg equilibrium for both BA patients and controls. The …
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W Udomsinprasert, T Tencomnao, S Honsawek… - World journal of pediatrics, 2012
