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AIM: To analyze plasma osteopontin levels and liver stiffness using transient elastography in postoperative biliary atresia (BA) children compared with healthy controls.

METHODS: Thirty children with postoperative BA and 10 normal controls were enrolled. The patients were categorized into two groups according to their jaundice status. Plasma levels of osteopontin were determined using commercially available enzyme-linked immunosorbent assay. Liver stiffness was measured by using transient elastography (Fibroscan). Ten validated Fibroscan measurements were performed in each patient and control with the result expressed in kilopascals (kPa).

RESULTS: Plasma osteopontin was significantly elevated in BA children compared with that of healthy controls (47.0±56.4 ng/mL vs 15.1±15.0 ng/mL, P= 0.01). The liver stiffness measurement was markedly elevated in the patients with BA compared with that of …