作者
Paul G Richardson, Albert Oriol, Meral Beksac, Anna Marina Liberati, Monica Galli, Fredrik Schjesvold, Jindriska Lindsay, Katja Weisel, Darrell White, Thierry Facon, Jesus San Miguel, Kazutaka Sunami, Peter O'Gorman, Pieter Sonneveld, Pawel Robak, Sergey Semochkin, Steve Schey, Xin Yu, Thomas Doerr, Amine Bensmaine, Tsvetan Biyukov, Teresa Peluso, Mohamed Zaki, Kenneth Anderson, Meletios Dimopoulos, Niels Abildgaard, Howard Adler, Fevzi Altuntas, Olga Meltem Akay, Bipinkumar Amin, Achilleas Anagnostopoulos, Larry Anderson, Pekka Anttila, Carla Araujo, Carlos Arce-Lara, Yildiz Aydin, Supratik Basu, Ramakrishna Battini, Thaddeus Beeker, Lotfi Benboubker, Dina Ben-Yehuda, Joan Bladé, Igor Wolfgang Blau, Ralph Boccia, Lillian Burke, Peter Byeff, Nicola Cascavilla, Michele Cavo, Andrew Chantry, Yen Charles, Arvind Chaudhry, Alessandro Corso, Mark Coyne, Felipe De Arriba, Sosana Delimpasi, Pierre Desjardins, Binod Dhakal, Paolo Di Bartolomeo, Francesco Di Raimondo, Jan Dürig, Monika Engelhardt, Martine Escoffre-Barbe, Graca Esteves, Max Flogegard, Nashat Gabrail, Barbara Gamberi, Mitchell Garrison, Julie Gay, Heinz Gisslinger, Hartmut Goldschmidt, Cristina Goncalves, Laurent Gressot, Sebastian Grosicki, Wahid Hanna, Patrick Hayden, Maria Manuela Henriques Bernardo, Robert Hermann, Viran Holden, Kirsti Honkalehto, Marianne Huben, John Huffman, Hannah Hunter, Marek Hus, Madan Jagasia, Sundar Jagganath, Murali Janakiram, Ishmael Jaiyesimi, Matthew Jenner, Cristina João, Peter Johnson, Artur Jurcyszyn, Sevgi Kalayoğlu Beşişik, Suman Kambhampati, Abraham Kanate, Ihsan Karadoğan, Ali Khojasteh, Dean Kirkel, Mieczyslaw Komarnicki, Maria-Theresa Krauth, Phillip Kuriakose, Alessandra Larocca, Birgitta Lauri, Xavier Leleu, Paulo Lucio, Mario Luppi, Silvia Mangiacavalli, Clara Mariette, Kosei Matsue, Ulf-Henri Mellqvist, Larisa Mendeleeva, Michael Meshad, Carole Miller, Ann Mohrbacher, Philippe Moreau, Anna Maria Morelli, Ercan Müldür, Anthony Naassan, Hareth Nahi, Rajesh Nair, Mike O'Dwyer, Seniz Öngören Aydin, Thomas Openshaw, Timothy O'Rourke, Michael Osswald, Lindsay Overton, Asmin Pati, Michel Pavic, Brigitte Pegourie, Mustafa Pehlivan, Ana Alfonso Pierola, Torben Plesner, Andrzej Pluta, Neil Rabin, Karthik Ramasamy, Alessandro Rambaldi, Paula Rodriguez, Christoph Röllig, Jacalyn Rosenblatt, Jonathan Rosenbluth, Morten Salomo, Olga Samoylova, Jose Sastre Moral, Hamdi Sati, Carmine Selleri, Salim Shafeek, Atsushi Shinagawa, Bethany Sleckman, Clay Smith, Mehmet Sonmez, Chester Stone
发表日期
2019/6/1
期刊
The Lancet Oncology
卷号
20
期号
6
页码范围
781-794
出版商
Elsevier
简介
Background
As lenalidomide becomes increasingly established for upfront treatment of multiple myeloma, patients refractory to this drug represent a population with an unmet need. The combination of pomalidomide, bortezomib, and dexamethasone has shown promising results in phase 1/2 trials of patients with relapsed or refractory multiple myeloma. We aimed to assess the efficacy and safety of this triplet regimen in patients with relapsed or refractory multiple myeloma who previously received lenalidomide.
Methods
We did a randomised, open-label, phase 3 trial at 133 hospitals and research centres in 21 countries. We enrolled patients (aged ≥18 years) with a diagnosis of multiple myeloma and measurable disease, an Eastern Cooperative Oncology Group performance status of 0–2, who received one to three previous regimens, including a lenalidomide-containing regimen for at least two consecutive cycles …
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PG Richardson, A Oriol, M Beksac, AM Liberati, M Galli… - The Lancet Oncology, 2019