作者
Ralmony de Alcantara Santos, Vinicius Guzzoni, Kleiton Augusto Santos Silva, Danielle Sanches Aragao, Rodolfo de Paula Vieira, Nádia Bertoncello, Nestor Schor, Flávio Aimbire, Dulce Elena Casarini, Tatiana Sousa Cunha
发表日期
2021/12/15
期刊
Life Sciences
卷号
287
页码范围
120058
出版商
Pergamon
简介
Aims
We aimed to determine whether resistance training (RT) regulates renal renin-angiotensin system (RAS) components and inflammatory mediators in diabetic rats.
Main methods
Male Wistar rats (3 months old) were randomly assigned into four groups: non-trained (NT), trained (T), non-trained + diabetes (NTD) and trained +diabetes (TD). Diabetes was induced by streptozotocin (50 mg/kg, Sigma Chemical Co., St. Louis, MO, USA), before RT protocol. Trained rats performed RT protocol on a 110-cm ladder (8 ladder climbs, once/day, 5 days/week, 8 weeks), carrying a load corresponding to 50–80% of maximum carrying capacity. Blood glucose, albuminuria and urinary volume were measured. Renal levels of angiotensin peptides (angiotensin I, II and 1–7), inflammatory markers, and also the activities of angiotensin-converting enzyme (ACE) and ACE2 were determined.
Key findings
Blood glucose and urinary …
学术搜索中的文章
R de Alcantara Santos, V Guzzoni, KAS Silva… - Life Sciences, 2021