作者
Konrad Szewczyk-Krolikowski, Ricarda AL Menke, Michal Rolinski, Eugene Duff, Gholamreza Salimi-Khorshidi, Nicola Filippini, Giovanna Zamboni, Michele TM Hu, Clare E Mackay
发表日期
2014/7/15
期刊
Neurology
卷号
83
期号
3
页码范围
208-214
出版商
Lippincott Williams & Wilkins
简介
Objective
To examine functional connectivity within the basal ganglia network (BGN) in a group of cognitively normal patients with early Parkinson disease (PD) on and off medication compared to age- and sex-matched healthy controls (HC), and to validate the findings in a separate cohort of participants with PD.
Methods
Participants were scanned with resting-state fMRI (RS-fMRI) at 3T field strength. Resting-state networks were isolated using independent component analysis. A BGN template was derived from 80 elderly HC participants. BGN maps were compared between 19 patients with PD on and off medication in the discovery group and 19 age- and sex-matched controls to identify a threshold for optimal group separation. The threshold was applied to 13 patients with PD (including 5 drug-naive) in the validation group to establish reproducibility of findings.
Results
Participants with PD showed reduced …
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