作者
Stefano Crippa, Alessandro Zerbi, Letizia Boninsegna, Vanessa Capitanio, Stefano Partelli, Gianpaolo Balzano, Paolo Pederzoli, Valerio Di Carlo, Massimo Falconi
发表日期
2012/3/19
期刊
Archives of Surgery
卷号
147
期号
3
页码范围
261-266
出版商
American Medical Association
简介
Objective
To analyze the characteristics and outcomes following enucleation and pancreatic resections of insulinomas.
Design
Retrospective cohort study; prospective database.
Settings
Academic, tertiary, and referral centers.
Patients
Consecutive patients with insulinomas (symptoms of hyperinsulinism and positive fasting glucose test) who underwent surgical treatment between January 1990 and December 2009.
Main Outcome Measures
Operative morbidity, tumor recurrence, and survival after treatment.
Results
A total of 198 patients (58.5% women; median age, 48 years) were identified. There were 175 (88%) neuroendocrine tumors grade G1 and 23 (12%) neuroendocrine tumors grade G2. Malignant insulinomas defined by lymph node/liver metastases were found in 7 patients (3.5%). Multiple insulinomas were found in 8% of patients, and 5.5% of patients had multiple endocrine neoplasia type 1. Surgical …
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S Crippa, A Zerbi, L Boninsegna, V Capitanio, S Partelli… - Archives of Surgery, 2012