作者
Sarah Van Belleghem, Leopoldo Torres Jr, Marco Santoro, Bhushan Mahadik, Arley Wolfand, Peter Kofinas, John P Fisher
发表日期
2020/1
期刊
Advanced functional materials
卷号
30
期号
3
页码范围
1907145
简介
Despite recent advances in clinical procedures, the repair of soft tissue remains a reconstructive challenge. Current technologies such as synthetic implants and dermal flap autografting result in inefficient shape retention and unpredictable aesthetic outcomes. 3D printing, however, can be leveraged to produce superior soft tissue grafts that allow enhanced host integration and volume retention. Here, a novel dual bioink 3D printing strategy is presented that utilizes synthetic and natural materials to create stable, biomimetic soft tissue constructs. A double network ink composed of covalently cross‐linked poly(ethylene) glycol and ionically cross‐linked alginate acts as a physical support network that promotes cell growth and enables long‐term graft shape retention. This is coupled with a cell‐laden, biodegradable gelatin methacrylate bioink in a hybrid printing technique, and the composite scaffolds are evaluated in …
引用总数
2020202120222023202482119142
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