作者
Jordan E Trachtenberg, Jesse K Placone, Brandon T Smith, Charlotte M Piard, Marco Santoro, David W Scott, John P Fisher, Antonios G Mikos
发表日期
2016/10/10
期刊
ACS Biomaterials Science & Engineering
卷号
2
期号
10
页码范围
1771-1780
出版商
American Chemical Society
简介
3D printing has emerged as an important technique for fabricating tissue engineered scaffolds. However, systematic evaluations of biomaterials for 3D printing have not been widely investigated. We evaluated poly(propylene fumarate) (PPF) as a model material for extrusion-based printing applications. A full-factorial design evaluating the effects of four factors (PPF concentration, printing pressure, printing speed, and programmed fiber spacing) on viscosity, fiber diameter, and pore size was performed layer-by-layer on 3D scaffolds. We developed a linear model of printing solution viscosity, where concentration of PPF had the greatest effect on viscosity, and the polymer exhibited shear thinning behavior. Additionally, linear models of pore size and fiber diameter revealed that fiber spacing and pressure had the greatest effect on pore size and fiber diameter, respectively, but interplay among the factors also …
学术搜索中的文章
JE Trachtenberg, JK Placone, BT Smith, CM Piard… - ACS Biomaterials Science & Engineering, 2016