作者
Dror Marchaim, Teena Chopra, Jason M Pogue, Federico Perez, Andrea M Hujer, Susan Rudin, Andrea Endimiani, Shiri Navon-Venezia, Jatinder Hothi, Jessica Slim, Christopher Blunden, Maryann Shango, Paul R Lephart, Hossein Salimnia, Deborah Reid, Judy Moshos, Wasif Hafeez, Suchitha Bheemreddy, Ting-Yi Chen, Sorabh Dhar, Robert A Bonomo, Keith S Kaye
发表日期
2011/2
期刊
Antimicrobial agents and chemotherapy
卷号
55
期号
2
页码范围
593-599
出版商
American Society for Microbiology
简介
Carbapenem-resistant Klebsiella pneumoniae has spread worldwide and throughout the United States. Colistin is used extensively to treat infections with this organism. We describe a cluster of colistin-resistant, carbapenem-resistant K. pneumoniae infection cases involving three institutions in Detroit, MI. A cluster of five cases of colistin-resistant, carbapenem-resistant K. pneumoniae was identified at Detroit Medical Center (DMC) from 27 July to 22 August 2009. Epidemiologic data were collected, and transmission opportunities were analyzed. Isolates were genotyped by using pulsed-field gel electrophoresis and repetitive extragenic palindromic PCR. Data regarding the use of colistin were obtained from pharmacy records. The index case of colistin-resistant, carbapenem-resistant K. pneumoniae was followed 20 days later by four additional cases occurring in a 6-day interval. All of the patients, at some point …
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D Marchaim, T Chopra, JM Pogue, F Perez, AM Hujer… - Antimicrobial agents and chemotherapy, 2011