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Amputee mobilisation requires prosthetic device use regardless of the amputation level and type. The socket is the most important part of the prosthesis and is manufactured by conventional methods worldwide. Recently, computer-aided design/computer-aided manufacturing systems have been frequently used in Europe and the United States for socket design. Use of the computer-aided design/computer-aided manufacturing method for socket production is increasing day by day. Are the sockets produced by this method advantageous or disadvantageous for amputees compared to the sockets produced by the conventional method? These results will provide guidance for units and centres that produce both above-knee and below-knee prostheses. For this purpose, we investigated whether there are differences between amputees fitted with conventional sockets and those fitted with computer-aided design/computer-aided manufacturing sockets in terms of their clinical characteristics and quality of life. In total, 56 patients, 28 fitted with a conventional socket (CS group) and 28 fitted with a computer-aided design/computer-aided manufacturing socket (CAD/CAM group), were included in the study. The duration of daily prosthetic use, walking time with the prosthesis, walking distance with the prosthesis, walking time with the prosthesis without pain, time of adaptation to the prosthesis, causes of amputation, and manufacturing and fitting time of the prosthesis were investigated. Quality of life was evaluated using the 36-item Short-Form Health Survey (SF-36) and Turkish version of the Trinity Amputation and Prosthesis …