作者
Jorge Gutiérrez‐Franco, Miriam Fabiola Ayón‐Pérez, Ma de Jesús Durán‐Avelar, Norberto Vibanco‐Pérez, Diego Eduardo Sánchez‐Jasso, Dulce Guadalupe Bañuelos‐Aguayo, Jaime Sánchez‐Meza, Helia Judith Pimentel‐Gutiérrez, José Francisco Zambrano‐Zaragoza, Juan Manuel Agraz‐Cibrián, Alejandro Vázquez‐Reyes
发表日期
2021/2
期刊
Molecular Genetics & Genomic Medicine
卷号
9
期号
2
页码范围
e1589
简介
Background
IKZF1 is a relevant gene associated with the pathogenesis of acute lymphoblastic leukemia, and the rs4132601 (T>G) and rs11978267 (A>G) polymorphisms have been associated with the development of this disease in several populations. The aim of this study was to determine the allelic and genotypic frequencies of the rs4132601 and rs11978267 polymorphisms in two indigenous Mexican groups (Cora and Huichol) and Mestizo populations from Nayarit, Mexico, and compare them with the frequencies of both polymorphisms in other populations of the world.
Methods
One hundred, 116, and 100 subjects from the Mestizo, Huichol, and Cora populations, respectively, all of them residents of the state of Nayarit, Mexico, were analyzed. The frequencies of rs4132601 and rs11978267 were determined by allelic discrimination using TaqMan assays.
Results
The allelic frequencies of rs4132601 were …
学术搜索中的文章
J Gutiérrez‐Franco, MF Ayón‐Pérez, MJ Durán‐Avelar… - Molecular Genetics & Genomic Medicine, 2021