作者
Nicholas D David, Feng Lin, Anton P Porsteinsson, Alzheimer's Disease Neuroimaging Initiative
发表日期
2016/1/1
期刊
The American Journal of Geriatric Psychiatry
卷号
24
期号
1
页码范围
70-80
出版商
Elsevier
简介
Objective
To characterize the course of neuropsychiatric symptoms (NPS) in adults with mild cognitive impairment (MCI), and to examine baseline individual-level predictors and associated cognitive and functional outcomes.
Design
A 2-year prospective cohort study.
Setting
Multicenter clinical settings.
Participants
Five hundred sixty individuals with MCI at baseline.
Measurements
NPS severity (measured using Neuropsychiatric Inventory Questionnaire) and cognitive and functional outcomes were assessed at baseline and every 6 months thereafter. Potential individual-level predictors were collected at baseline.
Results
Three latent classes of NPS courses were identified using growth mixture modeling: a stable class in which a low NPS burden remained relatively unchanged over time (N = 503, 89.8%); a worsened class in which an initially moderate NPS burden increased (N = 39, 7.0%); and an improved class in …
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ND David, F Lin, AP Porsteinsson… - The American Journal of Geriatric Psychiatry, 2016