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Background: The aim of the present study was to determine the effect of a chlorhexidine chip on crevicular prostaglandin E₂ (PGE₂) levels and on the clinical and microbiological parameters of periodontitis when used as adjunctive therapy to scaling and root planing (SRP) in patients with chronic periodontitis.

Methods: This randomized single‐blind study was carried out in parallel design. The test group received SRP plus chlorhexidine chip, whereas the control group received SRP alone. Thirty‐four subjects, aged 20 to 55 years, with chronic periodontitis were recruited. Clinical indices, microbiological samples, and gingival crevicular fluid (GCF) samples were evaluated at baseline and after 1, 3, and 6 months. Microbiological samples were evaluated under a light microscope. GCF PGE₂ levels were determined using radioimmunoassay.

Results: Significant improvements could be found for all clinical variables in …