作者
William M Souza, Mariene R Amorim, Renata Sesti-Costa, Lais D Coimbra, Natalia S Brunetti, Daniel A Toledo-Teixeira, Gabriela F de Souza, Stefanie P Muraro, Pierina L Parise, Priscilla P Barbosa, Karina Bispo-dos-Santos, Luciana S Mofatto, Camila L Simeoni, Ingra M Claro, Adriana SS Duarte, Thais M Coletti, Audrey B Zangirolami, Carolina Costa-Lima, Arilson BSP Gomes, Lucas I Buscaratti, Flavia C Sales, Vitor A Costa, Lucas AM Franco, Darlan S Candido, Oliver G Pybus, Jaqueline G de Jesus, Camila AM Silva, Mariana S Ramundo, Giulia M Ferreira, Mariana C Pinho, Leandro M Souza, Esmenia C Rocha, Pamela S Andrade, Myuki AE Crispim, Grazielle C Maktura, Erika R Manuli, Magnun NN Santos, Cecilia C Camilo, Rodrigo N Angerami, Maria L Moretti, Fernando R Spilki, Clarice W Arns, Marcelo Addas-Carvalho, Bruno D Benites, Marco AR Vinolo, Marcelo AS Mori, Nelson Gaburo, Christopher Dye, Henrique Marques-Souza, Rafael E Marques, Alessandro S Farias, Michael S Diamond, Nuno R Faria, Ester C Sabino, Fabiana Granja, Jose Luiz Proença-Módena
发表日期
2021/10/1
期刊
The Lancet Microbe
卷号
2
期号
10
页码范围
e527-e535
出版商
Elsevier
简介
Background
Mutations accrued by SARS-CoV-2 lineage P.1—first detected in Brazil in early January, 2021—include amino acid changes in the receptor-binding domain of the viral spike protein that also are reported in other variants of concern, including B.1.1.7 and B.1.351. We aimed to investigate whether isolates of wild-type P.1 lineage SARS-CoV-2 can escape from neutralising antibodies generated by a polyclonal immune response.
Methods
We did an immunological study to assess the neutralising effects of antibodies on lineage P.1 and lineage B isolates of SARS-CoV-2, using plasma samples from patients previously infected with or vaccinated against SARS-CoV-2. Two specimens (P.1/28 and P.1/30) containing SARS-CoV-2 lineage P.1 (as confirmed by viral genome sequencing) were obtained from nasopharyngeal and bronchoalveolar lavage samples collected from patients in Manaus, Brazil, and …
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WM Souza, MR Amorim, R Sesti-Costa, LD Coimbra… - The Lancet Microbe, 2021
