作者
Christopher D Paddock, Amy M Denison, R Ryan Lash, Lindy Liu, Brigid C Bollweg, F Scott Dahlgren, Cristina T Kanamura, Rodrigo N Angerami, Fabiana C Pereira dos Santos, Roosecelis Brasil Martines, Sandor E Karpathy
发表日期
2014/9/9
期刊
The American Journal of Tropical Medicine and Hygiene
卷号
91
期号
3
页码范围
589
出版商
The American Society of Tropical Medicine and Hygiene
简介
Rocky Mountain spotted fever (RMSF), a tick-borne zoonosis caused by Rickettsia rickettsii, is among the deadliest of all infectious diseases. To identify the distribution of various genotypes of R. rickettsii associated with fatal RMSF, we applied molecular typing methods to samples of DNA extracted from formalin-fixed, paraffin-embedded tissue specimens obtained at autopsy from 103 case-patients from seven countries who died of RMSF. Complete sequences of one or more intergenic regions were amplified from tissues of 30 (29%) case-patients and revealed a distribution of genotypes consisting of four distinct clades, including the Hlp clade, regarded previously as a non-pathogenic strain of R. rickettsii. Distinct phylogeographic patterns were identified when composite case-patient and reference strain data were mapped to the state and country of origin. The phylogeography of R. rickettsii is likely determined by …
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Phylogeography of Rickettsia rickettsii genotypes associated with fatal Rocky Mountain spotted fever
CD Paddock, AM Denison, RR Lash, L Liu, BC Bollweg… - The American Journal of Tropical Medicine and …, 2014