作者
Lixin Wang, Daoqiang Zhang, Changwen Zhang, Shuping Zhang, Zhe Wang, Chen Qu, Sijin Liu
发表日期
2012/1/1
期刊
Oncology letters
卷号
3
期号
1
页码范围
119-124
出版商
Spandidos Publications
简介
microRNAs (miRNAs) are involved in controlling tumor behaviors either as oncogenes or tumor suppressors. To elucidate the role of miRNAs in the regulation of tumor initiation, we delineated the microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. A group of miRNAs were differentially expressed in MDA-MB‑231 and SUM1315 cells (with a high proportion of breast cancer tumor‑initiating cells, CD44+ CD24-/low subpopulation) compared to MCF-7 cells (only a small proportion of CD44+ CD24-/low cells). Among the differentially expressed miRNAs common to MDA-MB‑231 and SUM1315, approximately 46% of them are suggested to regulate the'stemness' of stem cells or progenitor cells. Taken together, these findings suggested that miRNAs contribute to the maintenance of tumor‑initiating properties and indicate the potential value of the miRNA expression …
学术搜索中的文章
L Wang, D Zhang, C Zhang, S Zhang, Z Wang, C Qu… - Oncology letters, 2012