作者
Nishanthi Thalayasingam, Jonathan Massey, Amy E Anderson, Nisha Nair, Alex Clark, Andrew Skelton, Dennis W Lendrem, Julie Diboll, Louise N Reynard, Heather J Cordell, Stephen Eyre, Anne Barton, John D Isaacs, Arthur G Pratt
发表日期
2017/3/1
来源
Annals of the Rheumatic Diseases
卷号
76
期号
Suppl 1
页码范围
A56-A56
出版商
BMJ Publishing Group Ltd
简介
Background
Rheumatoid arthritis (RA) is a genetically complex disease of immune dysregulation. Genome-wide association scans (GWAS) have shown common variants at approximately 100 genetic loci to be associated with RA. Single nucleotide polymorphisms (SNPs) are typically intergenic and causative disease genes remain ill-defined. Examining how RA-associated SNPs influence gene expression in relevant biological contexts will begin to address this.
Methods
Patients naïve to immunomodulatory therapy attending the Newcastle Early Arthritis Clinic donated RNA and DNA, extracted from purified peripheral blood CD4+ T- and B-lymphocytes within 4 hours of blood draw. Detailed baseline and longitudinal clinical data were recorded for all participants, each followed up for >1 year. Genotyping and global gene expression measurement was carried out using the Illumina Human CoreExome array, and …
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N Thalayasingam, J Massey, AE Anderson, N Nair… - 2017