作者
Kun Li, Ya Ni, Yi He, Wen-Ying Chen, Jian-Xin Lu, C Yan Cheng, Ren-Shan Ge, Qi-Xian Shi
发表日期
2013/1
期刊
Human Reproduction
卷号
28
期号
1
页码范围
47–59
出版商
Oxford University Press
简介
STUDY QUESTION
Does adjudin disrupt chloride ion (Cl−) ion transport function in human sperm and impede sperm capacitation and fertilizing ability in vitro?
SUMMARY ANSWER
In this study the results indicate that adjudin is a potent blocker of Cl− channels: disrupting Cl− ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro.
WHAT IS KNOWN ALREADY
Although our previous studies have demonstrated that adjudin exerts its effect by disrupting sertoli-germ cell adhesion junctions, most notably apical ectoplasmic specialization by targeting testin and actin filament bundles that disrupts the actin-based cytoskeleton in sertoli cells, it remains unclear whether adjudin impedes Cl− ion transport function in the human sperm.
STUDY DESIGIN, SIZE AND DURATION
Semen samples were …
学术搜索中的文章
K Li, Y Ni, Y He, WY Chen, JX Lu, CY Cheng, RS Ge… - Human Reproduction, 2013