作者
Pradeepthi Bathala, Zeinab Fereshteh, Kun Li, Amal A Al-Dossary, Deni S Galileo, Patricia A Martin-DeLeon
发表日期
2018/3/1
期刊
MHR: Basic science of reproductive medicine
卷号
24
期号
3
页码范围
143-157
出版商
Oxford University Press
简介
STUDY QUESTIONS
Are extracellular vesicles (EVs) in the murine oviduct (oviductosomes, OVS) conserved in humans and do they play a role in the fertility of Pmca4−/− females?
SUMMARY ANSWER
OVS and their fertility-modulating proteins are conserved in humans, arise via the apocrine pathway, and mediate a compensatory upregulation of PMCA1 (plasma membrane Ca2+-ATPase 1) in Pmca4−/− female mice during proestrus/estrus, to account for their fertility.
WHAT IS KNOWN ALREADY
Recently murine OVS were identified and shown during proestrus/estrus to express elevated levels of PMCA4 which they can deliver to sperm. PMCA4 is the major Ca2+ efflux pump in murine sperm and Pmca4 deletion leads to loss of sperm motility and male infertility as there is no compensatory upregulation of the remaining Ca2+ pump, PMCA1. Of the four …
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P Bathala, Z Fereshteh, K Li, AA Al-Dossary… - MHR: Basic science of reproductive medicine, 2018