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Cortical parvalbumin-expressing (Pvalb⁺) neurons provide robust inhibition to neighboring pyramidal neurons, crucial for the proper functioning of cortical networks. This class of inhibitory neurons undergoes extensive synaptic formation and maturation during the first weeks after birth and continue to dynamically maintain their synaptic output throughout adulthood. While several transcription factors, such as Nkx2-1, Lhx6, and Sox6, are known to be necessary for the differentiation of progenitors into Pvalb⁺ neurons, which transcriptional programs underlie the postnatal maturation and maintenance of Pvalb⁺ neurons' innervation and synaptic function remains largely unknown. Because Sox6 is continuously expressed in Pvalb⁺ neurons until adulthood, we used conditional knock-out strategies to investigate its putative role in the postnatal maturation and synaptic function of cortical Pvalb⁺ neurons in mice of both …