作者
Alexander J Knights, Shanshan Liu, Yingxu Ma, Victoria S Nudell, Eric Perkey, Matthew J Sorensen, Robert T Kennedy, Ivan Maillard, Li Ye, Heejin Jun, Jun Wu
发表日期
2021/12/15
期刊
The EMBO journal
卷号
40
期号
24
页码范围
e106061
简介
Non‐neuronal cholinergic signaling, mediated by acetylcholine, plays important roles in physiological processes including inflammation and immunity. Our group first discovered evidence of non‐neuronal cholinergic circuitry in adipose tissue, whereby immune cells secrete acetylcholine to activate beige adipocytes during adaptive thermogenesis. Here, we reveal that macrophages are the cellular protagonists responsible for secreting acetylcholine to regulate thermogenic activation in subcutaneous fat, and we term these cells cholinergic adipose macrophages (ChAMs). An adaptive increase in ChAM abundance is evident following acute cold exposure, and macrophage‐specific deletion of choline acetyltransferase (ChAT), the enzyme for acetylcholine biosynthesis, impairs the cold‐induced thermogenic capacity of mice. Further, using pharmacological and genetic approaches, we show that ChAMs are …
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AJ Knights, S Liu, Y Ma, VS Nudell, E Perkey… - The EMBO journal, 2021