作者
Garance M Meyer, Barbara Hollunder, Ningfei Li, Konstantin Butenko, Till A Dembek, Lauren Hart, Cristina Nombela, Philip Mosley, Harith Akram, Nicola Acevedo, Benjamin M Borron, Tina Chou, Juan Pablo Castaño Montoya, Bryan Strange, Juan A Barcia, Himanshu Tyagi, David J Castle, Andrew H Smith, Ki Sueng Choi, Brian H Kopell, Helen S Mayberg, Sameer A Sheth, Wayne K Goodman, Albert FG Leentjens, R Mark Richardson, Susan L Rossell, Peter Bosanac, G Rees Cosgrove, Jens Kuhn, Veerle Visser-Vandewalle, Martijn Figee, Darin D Dougherty, Shan H Siddiqi, Ludvic Zrinzo, Eileen Joyce, Juan Carlos Baldermann, Michael D Fox, Clemens Neudorfer, Andreas Horn
发表日期
2024/7/15
期刊
Biological Psychiatry
卷号
96
期号
2
页码范围
101-113
出版商
Elsevier
简介
Background
Deep brain stimulation (DBS) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). Several stimulation targets have been used, mostly in and around the anterior limb of the internal capsule and ventral striatum. However, the precise target within this region remains a matter of debate.
Methods
Here, we retrospectively studied a multicenter cohort of 82 patients with OCD who underwent DBS of the ventral capsule/ventral striatum and mapped optimal stimulation sites in this region.
Results
DBS sweet-spot mapping performed on a discovery set of 58 patients revealed 2 optimal stimulation sites associated with improvements on the Yale-Brown Obsessive Compulsive Scale, one in the anterior limb of the internal capsule that overlapped with a previously identified OCD–DBS response tract and one in the region of the inferior thalamic peduncle and bed nucleus of the …
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GM Meyer, B Hollunder, N Li, K Butenko, TA Dembek… - Biological Psychiatry, 2024