作者
Antonio Abbate, Cory R Trankle, Leo F Buckley, Michael J Lipinski, Darryn Appleton, Dinesh Kadariya, Justin M Canada, Salvatore Carbone, Charlotte S Roberts, Nayef Abouzaki, Ryan Melchior, Sanah Christopher, Jeremy Turlington, George Mueller, James Garnett, Christopher Thomas, Roshanak Markley, George F Wohlford, Laura Puckett, Horacio Medina de Chazal, Juan G Chiabrando, Edoardo Bressi, Marco Giuseppe Del Buono, Aaron Schatz, Chau Vo, Dave L Dixon, Giuseppe G Biondi‐Zoccai, Michael C Kontos, Benjamin W Van Tassell
发表日期
2020/3/3
期刊
Journal of the American Heart Association
卷号
9
期号
5
页码范围
e014941
简介
Background
ST‐segment–elevation myocardial infarction is associated with an intense acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 blockade with anakinra significantly reduced the area under the curve for hsCRP (high sensitivity C‐reactive protein) levels during the first 14 days in patients with ST‐segment–elevation myocardial infarction (VCUART3 [Virginia Commonwealth University Anakinra Remodeling Trial 3]).
Methods and Results
We conducted a randomized, placebo‐controlled, double‐blind, clinical trial in 99 patients with ST‐segment–elevation myocardial infarction in which patients were assigned to 2 weeks treatment with anakinra once daily (N=33), anakinra twice daily (N=31), or placebo (N=35). hsCRP area under the curve was significantly lower in patients receiving anakinra versus placebo (median, 67 [interquartile range, 39–120] versus 214 …
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A Abbate, CR Trankle, LF Buckley, MJ Lipinski… - Journal of the American Heart Association, 2020