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Drop‐out is a prevalent complication in the analysis of data from longitudinal studies, and remains an active area of research for statisticians and other quantitative methodologists. This tutorial is designed to synthesize and illustrate the broad array of techniques that are used to address outcome‐related drop‐out, with emphasis on regression‐based methods. We begin with a review of important assumptions underlying likelihood‐based and semi‐parametric models, followed by an overview of models and methods used to draw inferences from incomplete longitudinal data. The majority of the tutorial is devoted to detailed analysis of two studies with substantial rates of drop‐out, designed to illustrate the use of effective methods that are relatively easy to apply: in the first example, we use both semi‐parametric and fully parametric models to analyse repeated binary responses from a clinical trial of smoking cessation …